Earlier today, it was announced that the Swede would miss the Magpies' preseason tour of the Far East due to a thigh injury.
With three years remaining on his contract, Newcastle's management is aware of Isak's desire to depart and are prepared to consider offers for the player.
Isak wants out of Newcastle
Newcastle striker Alexander Isak has informed club officials of his desire to leave the club, according to an exclusive report from the Daily Mail, via Sportal.
Liverpool were previously considered the frontrunners for Isak's signature but have since acquired Hugo Ekitike for £79 million.
However, British media speculate that the Merseyside club could still enter the race for the 25-year-old striker if either Darwin Nunez or Luis Diaz departs Anfield.
While Newcastle are reluctant to lose their star attacker, they would likely consider an offer of £120 million or more.