The Red Devils have struggled to find their form in the tournament and were on the verge of missing out on automatic qualification.
However, Ruben Amorim’s men were able to secure vital three points, defeating Plzen 2-1 on the night.
Rasmus Hojlund’s brace sealed the win for Man United after Andre Onana’s howler gave the home side the lead.
As it happened
Manchester United made five changes to the side that started their 3-2 loss to Nottingham Forest in the Premier League last weekend.
Viktoria Plzen made two changes to the side that won 2-1 at MFK Karvina in the Czech top flight last Sunday.
The first half failed to produce any goal as Man United played without confidence till the halftime break.
However, just entering into the second half, André Onana’s howler led to the home side scoring the first goal.
The Manchester United goalkeeper tried to pass the ball to Matthijs de Ligt, but it was cut out by Pavel Sulc, who laid the ball on a plate for Matej Vydra to put into an empty net.
The lead did not hold for long as Amad Diallo nutmegged the Viktoria defender before hitting a shot that deflected towards the path of Rasmus Hojlund to tap into an empty net.
Hojlund completed the comeback after Bruno Fernandes caught Viktoria out with a quick free-kick down low to Rasmus Hojlund, who flicked the ball past his marker and volleyed the ball into the far bottom corner.
Man United saw many chances to extend their lead but failed to convert their chances until the referee blew the whistle for full-time.